The Museum Pedro de Osma has paintings on linen cloth, metal, wood, glass and leather. They date from the XVI to XIX centuries, many are of well-known authors and, also, many are of anonymous painters. They are of aesthetic value and with special iconographic value. There are also non religious works: pictures of characters of the time and Incan subjects. All of them produced in the most important centers of cultural irradiation of the Peruvian Viceregency such as the cities of Cuzco, Arequipa, Ayacucho, Cajamarca, Trujillo, etc.

There are also paintings from The Alto Peru, Bolivia, Quito and Mexico as well as works from Spain, Germany and others of the Italian style.